Indirect Evidence for the Efficacy of Methotrexate in Diffuse Systemic

Indirect evidence for the efficacy of methotrexate in diffuse systemic sclerosis.

Acute methotrexate poisoning with diffuse rash: a case report

Background: Methotrexate is an anti-metabolite drug and one of the folic acid analog that it can play an important and functional role in the treatment of many malignancies and inflammatory diseases. However, the development of petechiae (maculopapular rash) is a very rare complication. Case Presentation: The patient was a 77 years old woman, Aryan race, who was known a case of severe and prog...

Statistical analysis of clinical and laboratory characteristics of systemic sclerosis

Background: Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by vasculopathy and excessive collagen deposition in the skin and internal organs. Based on the skin damage we divide the patients into two groups: limited and diffuse SSc. In restricted type, the thickness of the skin is limited in the face and distal parts of the elbows and knees, with less involveme...

Efficacy of Combination Therapy with Methotrexate and Misoprostol in Termination of Pregnancy in the First Trimester

Background: Induced abortion is the medical or surgical termination of pregnancy before fetal viability. It has maternal or fetal indications. The aim of the present study was to evaluate the efficacy of the combination of methotrexate and misoprostol for termination of the pregnancy in the first trimester. Methods: This analytic study was performed on 100 women at the first trimester of pregna...

Comparison of the efficacy of methotrexate and actinomycin D in the treatment of patients with stage I low risk gestational tro-phoblastic neoplasia (GTN)

  Background : Gestational trophoblastic neoplasia (GTN) refers to malignant lesions that arise from abnormal proliferation of placental trophoblast. Even in its metastatic forms GTN is curable with a cure rate of 90-100 %. Currently, methotrexate with or without folic acid, andactinomycin D is recommended for low risk GTN. The aim of this study is to compare the efficacy of methotrexate and ac...